Lipid A, a key component of

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{"type":"general","setup":"What does the mermaid wear to math class?","punchline":"Algae-bra.","id":393}

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{"type":"standard","title":"LPC-233","displaytitle":"LPC-233","namespace":{"id":0,"text":""},"wikibase_item":"Q130336920","titles":{"canonical":"LPC-233","normalized":"LPC-233","display":"LPC-233"},"pageid":77908859,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d7/LPC-233.svg/320px-LPC-233.svg.png","width":320,"height":199},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d7/LPC-233.svg/940px-LPC-233.svg.png","width":940,"height":585},"lang":"en","dir":"ltr","revision":"1246631214","tid":"667e4bee-7701-11ef-babe-1b314533e940","timestamp":"2024-09-20T03:35:37Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/LPC-233","revisions":"https://en.wikipedia.org/wiki/LPC-233?action=history","edit":"https://en.wikipedia.org/wiki/LPC-233?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:LPC-233"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/LPC-233","revisions":"https://en.m.wikipedia.org/wiki/Special:History/LPC-233","edit":"https://en.m.wikipedia.org/wiki/LPC-233?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:LPC-233"}},"extract":"LPC-233 is an experimental antibiotic drug. It acts as a potent and selective inhibitor of the bacterial enzyme UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC), which is important for the production of Lipid A, a key component of the cell membrane of Gram-negative bacteria. Various inhibitors of LpxC have been developed but none have yet progressed into clinical trials in humans, mostly because of off-target cardiovascular toxicity. LPC-233 is one of the most advanced drugs of this type in preclinical testing, showing activity against several pathogens of concern such as multidrug-resistant Pseudomonas aeruginosa and carbapenem resistant Enterobacter strains, and with no cardiovascular toxicity evident in testing on mice and dogs.","extract_html":"

LPC-233 is an experimental antibiotic drug. It acts as a potent and selective inhibitor of the bacterial enzyme UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC), which is important for the production of Lipid A, a key component of the cell membrane of Gram-negative bacteria. Various inhibitors of LpxC have been developed but none have yet progressed into clinical trials in humans, mostly because of off-target cardiovascular toxicity. LPC-233 is one of the most advanced drugs of this type in preclinical testing, showing activity against several pathogens of concern such as multidrug-resistant Pseudomonas aeruginosa and carbapenem resistant Enterobacter strains, and with no cardiovascular toxicity evident in testing on mice and dogs.

"}

{"type":"standard","title":"Alexandra Dulgheru","displaytitle":"Alexandra Dulgheru","namespace":{"id":0,"text":""},"wikibase_item":"Q231028","titles":{"canonical":"Alexandra_Dulgheru","normalized":"Alexandra Dulgheru","display":"Alexandra Dulgheru"},"pageid":22872764,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c2/Dulgheru_WMQ18_%289%29_%2828665180217%29.jpg/330px-Dulgheru_WMQ18_%289%29_%2828665180217%29.jpg","width":320,"height":479},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/c2/Dulgheru_WMQ18_%289%29_%2828665180217%29.jpg","width":3033,"height":4539},"lang":"en","dir":"ltr","revision":"1274554619","tid":"2687179e-e5b5-11ef-a606-f601afe6319c","timestamp":"2025-02-08T00:39:27Z","description":"Romanian tennis player","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Alexandra_Dulgheru","revisions":"https://en.wikipedia.org/wiki/Alexandra_Dulgheru?action=history","edit":"https://en.wikipedia.org/wiki/Alexandra_Dulgheru?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Alexandra_Dulgheru"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Alexandra_Dulgheru","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Alexandra_Dulgheru","edit":"https://en.m.wikipedia.org/wiki/Alexandra_Dulgheru?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Alexandra_Dulgheru"}},"extract":"Alexandra Dulgheru is a former professional tennis player from Romania. On 11 April 2011, she achieved a career-high singles ranking of world No. 26. Her best ranking in doubles is No. 41, which she reached on 4 July 2011.","extract_html":"

Alexandra Dulgheru is a former professional tennis player from Romania. On 11 April 2011, she achieved a career-high singles ranking of world No. 26. Her best ranking in doubles is No. 41, which she reached on 4 July 2011.

"}

{"slip": { "id": 32, "advice": "Everything in moderation, including moderation itself."}}

{"type":"standard","title":"Robert Guralnick","displaytitle":"Robert Guralnick","namespace":{"id":0,"text":""},"wikibase_item":"Q28104219","titles":{"canonical":"Robert_Guralnick","normalized":"Robert Guralnick","display":"Robert Guralnick"},"pageid":57893712,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/0/04/Robert_Guralnick.jpg/330px-Robert_Guralnick.jpg","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/0/04/Robert_Guralnick.jpg","width":400,"height":300},"lang":"en","dir":"ltr","revision":"1235252696","tid":"773ff6aa-44f9-11ef-a03b-b34466d09487","timestamp":"2024-07-18T11:32:51Z","description":"American mathematician","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Robert_Guralnick","revisions":"https://en.wikipedia.org/wiki/Robert_Guralnick?action=history","edit":"https://en.wikipedia.org/wiki/Robert_Guralnick?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Robert_Guralnick"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Robert_Guralnick","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Robert_Guralnick","edit":"https://en.m.wikipedia.org/wiki/Robert_Guralnick?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Robert_Guralnick"}},"extract":"Robert Michael Guralnick is an American mathematician known for his work in group theory. He works as a Professor of Mathematics at the University of Southern California.","extract_html":"

Robert Michael Guralnick is an A